Parkinson’s disease is the most common neurodegenerative movement disorder for which we have no cure. It is associated with prominent death of dopamine-producing neurons in the brain. The mainstays of treatment are dopaminergic therapies and neuromodulation. However these therapies only alleviate symptoms and there are no available treatments that slow or stop the progressive neurodegeneration.
Our research programs are based on the hypothesis that understanding the molecular mechanisms underlying neuronal death in Parkinson’s disease and other movement disorders will lead to the discovery of these much needed disease-modifying therapies.
We use a collaborative and comprehensive approach by leveraging molecular biology techniques, in vitro cellular models, in vivo invertebrate and vertebrate systems, and patient biospecimens.
Our ultimate goal is to discover a cure for Parkinson’s disease and other movement disorders.