Publications - Kalia Labs

Lorraine V. Kalia

Takeuchi, LE, Kalia, LV, Simmons, CA. Vascular models of Alzheimer's disease: An overview of recent in vitro models of the blood-brain barrier. Neurobiol Dis. 2025;208 :106864. doi: 10.1016/j.nbd.2025.106864. PubMed PMID:40089165 .

Martinez-Nunez, AE, Rozell, CJ, Little, S, Tan, H, Schmidt, SL, Grill, WM et al.. Proceedings of the 12th annual deep brain stimulation think tank: cutting edge technology meets novel applications. Front Hum Neurosci. 2025;19 :1544994. doi: 10.3389/fnhum.2025.1544994. PubMed PMID:40070487 PubMed Central PMC11893992.

Bloem, BR, Kalia, LV. Rong Xue, Xuang Zhang, and Anette Schrag, recipients of the Parkinson Prize 2023. J Parkinsons Dis. 2025;15 (1):3-5. doi: 10.1177/1877718X241311700. PubMed PMID:39973497 .

Devos, D, Rascol, O, Meissner, WG, Foubert-Samier, A, Lewis, S, Tranchant, C et al.. Therapeutic modalities of deferiprone in Parkinson's disease: SKY and EMBARK studies. J Parkinsons Dis. 2025;15 (1):72-86. doi: 10.1177/1877718X241300295. PubMed PMID:39973479 .

Kalia, LV. First phase 3 trial of GLP-1 receptor agonist for neurodegeneration. Lancet. 2025;405 (10479):598-599. doi: 10.1016/S0140-6736(25)00161-8. PubMed PMID:39919774 .

Cho, N, Kalia, LV, Kalia, SK. Re-examining the pathobiological basis of gait dysfunction in Parkinson's disease. Trends Neurosci. 2025;48 (3):189-199. doi: 10.1016/j.tins.2025.01.002. PubMed PMID:39884904 .

Koch, MW, Kalia, LV, Sarna, JR, Wile, D, Mestre, TA, Schlossmacher, MG et al.. Feasibility of Simon 2-Stage Futility Trials in Early Parkinson Disease: Analysis of the PRECEPT and DATATOP Trial Datasets. Neurology. 2025;104 (1):e210079. doi: 10.1212/WNL.0000000000210079. PubMed PMID:39642339 .

Kalia, LV, Asis, A, Arbour, N, Bar-Or, A, Bove, R, Di Luca, DG et al.. Disease-modifying therapies for Parkinson disease: lessons from multiple sclerosis. Nat Rev Neurol. 2024;20 (12):724-737. doi: 10.1038/s41582-024-01023-0. PubMed PMID:39375563 .

Berg, D, Bloem, BR, Kalia, LV, Postuma, RB. Introduction: The Earliest Phase of Parkinson's Disease: Possibilities for Detection and Intervention. J Parkinsons Dis. 2024;14 (s2):S253-S255. doi: 10.3233/JPD-249011. PubMed PMID:39331112 PubMed Central PMC11492101.

Cressatti, M, Pinilla-Monsalve, GD, Blais, M, Normandeau, CP, Degroot, C, Kathol, I et al.. Advancing Parkinson's Disease Research in Canada: The Canadian Open Parkinson Network (C-OPN) Cohort. J Parkinsons Dis. 2024;14 (7):1481-1494. doi: 10.3233/JPD-240213. PubMed PMID:39302382 PubMed Central PMC11492019.

Kalia, LV, Berg, D, Kordower, JH, Shannon, KM, Taylor, JP, Cardoso, F et al.. International Parkinson and Movement Disorder Society Viewpoint on Biological Frameworks of Parkinson's Disease: Current Status and Future Directions. Mov Disord. 2024;39 (10):1710-1715. doi: 10.1002/mds.30007. PubMed PMID:39250594 .

Kukkle, PL, Kalia, LV, Habib, A, Jagota, P, Ojha, R, Kandadai, RM et al.. Levodopa Equivalent Daily Dosage: Geographical Variations and Real-Life Modules in Parkinson's Disease. Mov Disord Clin Pract. 2024;11 (11):1388-1395. doi: 10.1002/mdc3.14200. PubMed PMID:39215556 PubMed Central PMC11542276.

Piran, S, Nimmo, GAM, Chaboureau, A, Mohankumar, R, Kalia, LV, Amato, D et al.. The natural history of Gaucher disease type 1 in 31 patients over a median of 15 years: a retrospective study. Intern Med J. 2024;54 (10):1661-1668. doi: 10.1111/imj.16503. PubMed PMID:39189706 .

Kalbe, E, Bloem, BR, Kalia, LV, Nieuwboer, A. Special Issue: Non-Pharmacological Interventions for People with Parkinson's Disease: Are We Entering a New Era?. J Parkinsons Dis. 2024;14 (s1):S1-S4. doi: 10.3233/JPD-249009. PubMed PMID:39150834 PubMed Central PMC11380231.

Earnshaw, R, Zhang, YT, Heymann, G, Fujisawa, K, Hui, S, Kapadia, M et al.. Disease-associated mutations in C-terminus of HSP70 interacting protein (CHIP) impair its ability to negatively regulate mitophagy. Neurobiol Dis. 2024;200 :106625. doi: 10.1016/j.nbd.2024.106625. PubMed PMID:39117117 .

George, J, Shafiq, K, Kapadia, M, Kalia, LV, Kalia, SK. High frequency electrical stimulation reduces α-synuclein levels and α-synuclein-mediated autophagy dysfunction. Sci Rep. 2024;14 (1):16091. doi: 10.1038/s41598-024-64131-3. PubMed PMID:38997273 PubMed Central PMC11245498.

Beckers, M, Coburn, B, Kalia, LV, Bloem, BR. A Randomized Controlled Trial of Fecal Microbiota Transplantation for Parkinson's Disease: Getting it right, if not PARFECT. J Parkinsons Dis. 2024;14 (5):913-915. doi: 10.3233/JPD-249007. PubMed PMID:38968058 PubMed Central PMC11307084.

Burré, J, Edwards, RH, Halliday, G, Lang, AE, Lashuel, HA, Melki, R et al.. Research Priorities on the Role of α-Synuclein in Parkinson's Disease Pathogenesis. Mov Disord. 2024;39 (10):1663-1678. doi: 10.1002/mds.29897. PubMed PMID:38946200 PubMed Central PMC11808831.

Meng, Y, Kalia, LV, Kalia, SK, Hamani, C, Huang, Y, Hynynen, K et al.. Current Progress in Magnetic Resonance-Guided Focused Ultrasound to Facilitate Drug Delivery across the Blood-Brain Barrier. Pharmaceutics. 2024;16 (6):. doi: 10.3390/pharmaceutics16060719. PubMed PMID:38931843 PubMed Central PMC11206305.

Gros, P, Spee, BTM, Bloem, BR, Kalia, LV. If Art Were a Drug: Implications for Parkinson's Disease. J Parkinsons Dis. 2024;14 (s1):S159-S172. doi: 10.3233/JPD-240031. PubMed PMID:38788090 PubMed Central PMC11380257.

Hui, S, George, J, Kapadia, M, Chau, H, Bariring, Z, Earnshaw, R et al.. Mitophagy Upregulation Occurs Early in the Neurodegenerative Process Mediated by α-Synuclein. Mol Neurobiol. 2024;61 (11):9032-9042. doi: 10.1007/s12035-024-04131-6. PubMed PMID:38581539 PubMed Central PMC11496319.

Davidson, B, Milosevic, L, Kondrataviciute, L, Kalia, LV, Kalia, SK. Neuroscience fundamentals relevant to neuromodulation: Neurobiology of deep brain stimulation in Parkinson's disease. Neurotherapeutics. 2024;21 (3):e00348. doi: 10.1016/j.neurot.2024.e00348. PubMed PMID:38579455 PubMed Central PMC11000190.

Outeiro, TF, Kalia, LV, Bezard, E, Ferrario, J, Lin, CH, Salama, M et al.. Basic Science in Movement Disorders: Fueling the Engine of Translation into Clinical Practice. Mov Disord. 2024;39 (6):929-933. doi: 10.1002/mds.29802. PubMed PMID:38576081 .

Schneider, RB, Phillips, O, Kalia, L. Conventionvs. Innovation I: Digital technology will replace clinic-based care in Parkinson disease. Parkinsonism Relat Disord. 2024;126 :106067. doi: 10.1016/j.parkreldis.2024.106067. PubMed PMID:38443214 .

Lee, EJ, Aguirre-Padilla, DH, Fomenko, A, Pawar, G, Kapadia, M, George, J et al.. Reduction of alpha-synuclein oligomers in preclinical models of Parkinson's disease by electrical stimulation in vitro and deep brain stimulation in vivo. Brain Stimul. 2024;17 (2):166-175. doi: 10.1016/j.brs.2024.02.005. PubMed PMID:38342364 .

Bloem, BR, Kalia, LV. Kathrin Brockmann, Milan Zimmermann, and Dareia Roos, Recipients of The Parkinson Prize 2023. J Parkinsons Dis. 2023;13 (8):1273-1276. doi: 10.3233/JPD-239006. PubMed PMID:38143375 PubMed Central PMC10741366.

Bhidayasiri, R, Kalia, LV, Bloem, BR. Tackling Parkinson's Disease as a Global Challenge. J Parkinsons Dis. 2023;13 (8):1277-1280. doi: 10.3233/JPD-239005. PubMed PMID:38143374 PubMed Central PMC10741319.

Mestre, TA, Kalia, LV. α-synuclein seed amplification in Parkinson's disease. Lancet Neurol. 2023;22 (11):984-985. doi: 10.1016/S1474-4422(23)00374-5. PubMed PMID:37863603 .

Albanese, F, Bloem, BR, Kalia, LV. Addressing the "Replication Crisis" in the Field of Parkinson's Disease. J Parkinsons Dis. 2023;13 (6):849-850. doi: 10.3233/JPD-239002. PubMed PMID:37694309 PubMed Central PMC10578279.

Lang, S, Vetkas, A, Conner, C, Kalia, LV, Lozano, AM, Kalia, SK et al.. Predictors of Future Deep Brain Stimulation Surgery in de novo Parkinson's Disease. Mov Disord Clin Pract. 2023;10 (6):933-942. doi: 10.1002/mdc3.13747. PubMed PMID:37332645 PubMed Central PMC10272891.

Nim, S, O'Hara, DM, Corbi-Verge, C, Perez-Riba, A, Fujisawa, K, Kapadia, M et al.. Disrupting the α-synuclein-ESCRT interaction with a peptide inhibitor mitigates neurodegeneration in preclinical models of Parkinson's disease. Nat Commun. 2023;14 (1):2150. doi: 10.1038/s41467-023-37464-2. PubMed PMID:37076542 PubMed Central PMC10115881.

McFarthing, K, Bloem, BR, Kalia, LV. People with Parkinson's as Partners for the Journal of Parkinson's Disease. J Parkinsons Dis. 2023;13 (2):125-126. doi: 10.3233/JPD-239000. PubMed PMID:36911950 PubMed Central PMC10041413.

Kalia, LV, Nimmo, GAM, Mestre, TA. Genetic Testing in Clinical Movement Disorders: A Case-Based Review. Semin Neurol. 2023;43 (1):147-155. doi: 10.1055/s-0043-1763507. PubMed PMID:36854393 .

Bloem, BR, Kalia, LV. The Journal of Parkinson's Disease Takes the Open Road. J Parkinsons Dis. 2023;13 (1):1-2. doi: 10.3233/JPD-229011. PubMed PMID:36744347 PubMed Central PMC9912718.

Bloem, BR, Kalia, LV. Thomas G. Beach, MD, PhD, FRCPC, Charles H. Adler, MD, PhD, FAAN, and Simon Stott, PhD, recipients of the Parkinson Prize 2022. J Parkinsons Dis. 2022;12 (8):2283-2286. doi: 10.3233/JPD-229010. PubMed PMID:36565068 .

Huang, Y, Meng, Y, Pople, CB, Bethune, A, Jones, RM, Abrahao, A et al.. Cavitation Feedback Control of Focused Ultrasound Blood-Brain Barrier Opening for Drug Delivery in Patients with Parkinson's Disease. Pharmaceutics. 2022;14 (12):. doi: 10.3390/pharmaceutics14122607. PubMed PMID:36559101 PubMed Central PMC9781334.

Fereshtehnejad, SM, Saleh, PA, Oliveira, LM, Patel, N, Bhowmick, S, Saranza, G et al.. Movement disorders in hereditary spastic paraplegia (HSP): a systematic review and individual participant data meta-analysis. Neurol Sci. 2023;44 (3):947-959. doi: 10.1007/s10072-022-06516-8. PubMed PMID:36441344 PubMed Central PMC9925593.

Kalia, LV. First trials test targeting of α-synuclein for Parkinson disease. Nat Rev Neurol. 2022;18 (12):703-704. doi: 10.1038/s41582-022-00726-6. PubMed PMID:36151474 .

Meng, Y, Pople, CB, Huang, Y, Jones, RM, Ottoy, J, Goubran, M et al.. Putaminal Recombinant Glucocerebrosidase Delivery with Magnetic Resonance-Guided Focused Ultrasound in Parkinson's Disease: A Phase I Study. Mov Disord. 2022;37 (10):2134-2139. doi: 10.1002/mds.29190. PubMed PMID:36089809 .

Ghadery, CM, Kalia, LV, Connolly, BS. Movement disorders of the mouth: a review of the common phenomenologies. J Neurol. 2022;269 (11):5812-5830. doi: 10.1007/s00415-022-11299-1. PubMed PMID:35904592 .

Kalia, LV, Bloem, BR. A New Chapter for the Journal of Parkinson's Disease. J Parkinsons Dis. 2022;12 (5):1365-1367. doi: 10.3233/JPD-229004. PubMed PMID:35811539 .

Sáenz-Farret, M, Lang, AE, Kalia, L, Cunha, I, Sousa, M, Kuhlman, G et al.. Spastic Paraplegia Type 7 and Movement Disorders: Beyond the Spastic Paraplegia. Mov Disord Clin Pract. 2022;9 (4):522-529. doi: 10.1002/mdc3.13437. PubMed PMID:35586535 PubMed Central PMC9092757.

Chen, KS, Menezes, K, Rodgers, JB, O'Hara, DM, Tran, N, Fujisawa, K et al.. Small molecule inhibitors of α-synuclein oligomers identified by targeting early dopamine-mediated motor impairment in C. elegans. Mol Neurodegener. 2021;16 (1):77. doi: 10.1186/s13024-021-00497-6. PubMed PMID:34772429 PubMed Central PMC8588601.

Oliveira, LM, Rastin, T, Nimmo, GAM, Ross, JP, Dion, PA, Zhang, M et al.. Occurrence of Amyotrophic Lateral Sclerosis in Type 1 Gaucher Disease. Neurol Genet. 2021;7 (4):e600. doi: 10.1212/NXG.0000000000000600. PubMed PMID:34017912 PubMed Central PMC8130998.

Barbuti, PA, Barker, RA, Brundin, P, Przedborski, S, Papa, SM, Kalia, LV et al.. Recent Advances in the Development of Stem-Cell-Derived Dopaminergic Neuronal Transplant Therapies for Parkinson's Disease. Mov Disord. 2021;36 (8):1772-1780. doi: 10.1002/mds.28628. PubMed PMID:33963552 .

O'Hara, DM, Kapadia, M, Ping, S, Kalia, SK, Kalia, LV. Semi-Quantitative Determination of Dopaminergic Neuron Density in the Substantia Nigra of Rodent Models using Automated Image Analysis. J Vis Exp. 2021; (168):. doi: 10.3791/62062. PubMed PMID:33616088 .

Bloem, BR, Trenkwalder, C, Sanchez-Ferro, A, Kalia, LV, Alcalay, R, Chiang, HL et al.. COVID-19 Vaccination for Persons with Parkinson's Disease: Light at the End of the Tunnel?. J Parkinsons Dis. 2021;11 (1):3-8. doi: 10.3233/JPD-212573. PubMed PMID:33523021 PubMed Central PMC7990445.

Branfield Day, L, Rajendram, P, Kalia, LV, Gold, WL. An Intelligent Diagnosis: SMART Syndrome. Am J Med. 2021;134 (7):863-865. doi: 10.1016/j.amjmed.2020.11.034. PubMed PMID:33444593 .

Saranza, G, Chen, KS, Ganos, C, Kalia, LV, Chen, R, Lang, AE et al.. Botulinum Toxin-Associated Prolonged Remission of Idiopathic Cervical Dystonia. Can J Neurol Sci. 2021;48 (6):864-868. doi: 10.1017/cjn.2020.280. PubMed PMID:33397526 .

Visanji, NP, Madan, P, Lacoste, AMB, Buleje, I, Han, Y, Spangler, S et al.. Using artificial intelligence to identify anti-hypertensives as possible disease modifying agents in Parkinson's disease. Pharmacoepidemiol Drug Saf. 2021;30 (2):201-209. doi: 10.1002/pds.5176. PubMed PMID:33219601 .

Mylvaganam, S, Earnshaw, R, Heymann, G, Kalia, SK, Kalia, LV. C-terminus of Hsp70 Interacting Protein (CHIP) and Neurodegeneration: Lessons from the Bench and Bedside. Curr Neuropharmacol. 2021;19 (7):1038-1068. doi: 10.2174/1570159X18666201116145507. PubMed PMID:33200713 PubMed Central PMC8686314.

Mukherjee, T, Ramaglia, V, Abdel-Nour, M, Bianchi, AA, Tsalikis, J, Chau, HN et al.. The eIF2α kinase HRI triggers the autophagic clearance of cytosolic protein aggregates. J Biol Chem. 2021;296 :100050. doi: 10.1074/jbc.RA120.014415. PubMed PMID:33168630 PubMed Central PMC7948985.

Kapadia, M, De Snoo, ML, Kalia, LV, Kalia, SK. Regulation of Parkin-dependent mitophagy by Bcl-2-associated athanogene (BAG) family members. Neural Regen Res. 2021;16 (4):684-685. doi: 10.4103/1673-5374.295330. PubMed PMID:33063725 PubMed Central PMC8067924.

Friesen, EL, Zhang, YT, Earnshaw, R, De Snoo, ML, O'Hara, DM, Agapova, V et al.. BAG5 Promotes Alpha-Synuclein Oligomer Formation and Functionally Interacts With the Autophagy Adaptor Protein p62. Front Cell Dev Biol. 2020;8 :716. doi: 10.3389/fcell.2020.00716. PubMed PMID:32850835 PubMed Central PMC7417480.

Meng, Y, Pople, CB, Kalia, SK, Kalia, LV, Davidson, B, Bigioni, L et al.. Cost-effectiveness analysis of MR-guided focused ultrasound thalamotomy for tremor-dominant Parkinson's disease. J Neurosurg. 2021;135 (1):273-278. doi: 10.3171/2020.5.JNS20692. PubMed PMID:32764177 .

O'Hara, DM, Pawar, G, Kalia, SK, Kalia, LV. LRRK2 and α-Synuclein: Distinct or Synergistic Players in Parkinson's Disease?. Front Neurosci. 2020;14 :577. doi: 10.3389/fnins.2020.00577. PubMed PMID:32625052 PubMed Central PMC7311858.

Fomenko, A, Lee, DJ, McKinnon, C, Lee, EJ, de Snoo, ML, Gondard, E et al.. Deep Brain Stimulation of the Medial Septal Nucleus Induces Expression of a Virally Delivered Reporter Gene in Dentate Gyrus. Front Neurosci. 2020;14 :463. doi: 10.3389/fnins.2020.00463. PubMed PMID:32477058 PubMed Central PMC7235415.

Maclagan, LC, Visanji, NP, Cheng, Y, Tadrous, M, Lacoste, AMB, Kalia, LV et al.. Identifying drugs with disease-modifying potential in Parkinson's disease using artificial intelligence and pharmacoepidemiology. Pharmacoepidemiol Drug Saf. 2020;29 (8):864-872. doi: 10.1002/pds.5015. PubMed PMID:32410265 .

O'Hara, DM, Kalia, SK, Kalia, LV. Methods for detecting toxic α-synuclein species as a biomarker for Parkinson's disease. Crit Rev Clin Lab Sci. 2020;57 (5):291-307. doi: 10.1080/10408363.2019.1711359. PubMed PMID:32116096 .

Espay, AJ, Kalia, LV, Gan-Or, Z, Williams-Gray, CH, Bedard, PL, Rowe, SM et al.. Disease modification and biomarker development in Parkinson disease: Revision or reconstruction?. Neurology. 2020;94 (11):481-494. doi: 10.1212/WNL.0000000000009107. PubMed PMID:32102975 PubMed Central PMC7220234.

McKinnon, C, De Snoo, ML, Gondard, E, Neudorfer, C, Chau, H, Ngana, SG et al.. Early-onset impairment of the ubiquitin-proteasome system in dopaminergic neurons caused by α-synuclein. Acta Neuropathol Commun. 2020;8 (1):17. doi: 10.1186/s40478-020-0894-0. PubMed PMID:32059750 PubMed Central PMC7023783.

De Snoo, ML, Friesen, EL, Zhang, YT, Earnshaw, R, Dorval, G, Kapadia, M et al.. Bcl-2-associated athanogene 5 (BAG5) regulates Parkin-dependent mitophagy and cell death. Cell Death Dis. 2019;10 (12):907. doi: 10.1038/s41419-019-2132-x. PubMed PMID:31787745 PubMed Central PMC6885512.

Kalia, LV. Expert comment: "A case of missing pathology in a patient with LRRK2 Parkinson's disease". Parkinsonism Relat Disord. 2020;74 :78-79. doi: 10.1016/j.parkreldis.2019.11.005. PubMed PMID:31727562 .

Kalia, LV, Jellinger, KA. Multiple system atrophy and myoclonus: A morphologic marker in the spinal cord?. Neurology. 2019;93 (7):287-288. doi: 10.1212/WNL.0000000000007941. PubMed PMID:31405931 .

Rajalingam, R, Breen, DP, Chen, R, Fox, S, Kalia, LV, Munhoz, RP et al.. The clinical significance of lower limb tremors. Parkinsonism Relat Disord. 2019;65 :165-171. doi: 10.1016/j.parkreldis.2019.06.007. PubMed PMID:31201091 .

McKinnon, C, Gros, P, Lee, DJ, Hamani, C, Lozano, AM, Kalia, LV et al.. Deep brain stimulation: potential for neuroprotection. Ann Clin Transl Neurol. 2019;6 (1):174-185. doi: 10.1002/acn3.682. PubMed PMID:30656196 PubMed Central PMC6331208.

Kalia, LV. Diagnostic biomarkers for Parkinson's disease: focus on α-synuclein in cerebrospinal fluid. Parkinsonism Relat Disord. 2019;59 :21-25. doi: 10.1016/j.parkreldis.2018.11.016. PubMed PMID:30466800 .

Picillo, M, Lizarraga, KJ, Friesen, EL, Chau, H, Zhang, M, Sato, C et al.. Parkinsonism due to A53E α-synuclein gene mutation: Clinical, genetic, epigenetic, and biochemical features. Mov Disord. 2018;33 (12):1950-1955. doi: 10.1002/mds.27506. PubMed PMID:30423204 .

Coakeley, S, Ang, LC, Jansen, GH, Cho, SS, Lang, AE, Houle, S et al.. [¹⁸ F]AV-1451 binding and postmortem pathology of CBD. Mov Disord. 2018;33 (8):1360-1361. doi: 10.1002/mds.27356. PubMed PMID:30136331 .

Ruskey, JA, Zhou, S, Santiago, R, Franche, LA, Alam, A, Roncière, L et al.. The GBA p.Trp378Gly mutation is a probable French-Canadian founder mutation causing Gaucher disease and synucleinopathies. Clin Genet. 2018;94 (3-4):339-345. doi: 10.1111/cge.13405. PubMed PMID:29920646 .

O'Hara, DM, Kalia, SK, Kalia, LV. Emerging disease-modifying strategies targeting α-synuclein for the treatment of Parkinson's disease. Br J Pharmacol. 2018;175 (15):3080-3089. doi: 10.1111/bph.14345. PubMed PMID:29722028 PubMed Central PMC6031880.

Meng, Y, Voisin, MR, Suppiah, S, Kalia, SK, Kalia, LV, Hamani, C et al.. Is there a role for MR-guided focused ultrasound in Parkinson's disease?. Mov Disord. 2018;33 (4):575-579. doi: 10.1002/mds.27308. PubMed PMID:29476631 .

Baskin, B, Kalia, LV, Banwell, BL, Ray, PN, Yoon, G. Complex genomic rearrangement in SPG11 due to a DNA replication-based mechanism. Mov Disord. 2017;32 (12):1792-1794. doi: 10.1002/mds.27188. PubMed PMID:29082553 .

Friesen, EL, De Snoo, ML, Rajendran, L, Kalia, LV, Kalia, SK. Chaperone-Based Therapies for Disease Modification in Parkinson's Disease. Parkinsons Dis. 2017;2017 :5015307. doi: 10.1155/2017/5015307. PubMed PMID:28913005 PubMed Central PMC5585656.

Park, S, Bin, NR, Yu, B, Wong, R, Sitarska, E, Sugita, K et al.. UNC-18 and Tomosyn Antagonistically Control Synaptic Vesicle Priming Downstream of UNC-13 in Caenorhabditis elegans. J Neurosci. 2017;37 (36):8797-8815. doi: 10.1523/JNEUROSCI.0338-17.2017. PubMed PMID:28821673 PubMed Central PMC5588468.

Kalia, LV. Biomarkers for cognitive dysfunction in Parkinson's disease. Parkinsonism Relat Disord. 2018;46 Suppl 1 :S19-S23. doi: 10.1016/j.parkreldis.2017.07.023. PubMed PMID:28781202 .

Koprich, JB, Kalia, LV, Brotchie, JM. Animal models of α-synucleinopathy for Parkinson disease drug development. Nat Rev Neurosci. 2017;18 (9):515-529. doi: 10.1038/nrn.2017.75. PubMed PMID:28747776 .

Rosborough, K, Patel, N, Kalia, LV. α-Synuclein and Parkinsonism: Updates and Future Perspectives. Curr Neurol Neurosci Rep. 2017;17 (4):31. doi: 10.1007/s11910-017-0737-y. PubMed PMID:28324300 .

Breen, DP, Kalia, LV. Exploiting the aggregation properties of alpha-synuclein for diagnostic purposes. Mov Disord. 2017;32 (1):106. doi: 10.1002/mds.26884. PubMed PMID:27896833 .

Visanji, NP, Brotchie, JM, Kalia, LV, Koprich, JB, Tandon, A, Watts, JC et al.. α-Synuclein-Based Animal Models of Parkinson's Disease: Challenges and Opportunities in a New Era. Trends Neurosci. 2016;39 (11):750-762. doi: 10.1016/j.tins.2016.09.003. PubMed PMID:27776749 .

Rowland, NC, Kalia, SK, Kalia, LV, Larson, PS, Lim, DA, Bankiewicz, KS et al.. Merging DBS with viral vector or stem cell implantation: "hybrid" stereotactic surgery as an evolution in the surgical treatment of Parkinson's disease. Mol Ther Methods Clin Dev. 2016;3 :15051. doi: 10.1038/mtm.2015.51. PubMed PMID:26817024 PubMed Central PMC4714520.

Kalia, LV, Lang, AE. Parkinson disease in 2015: Evolving basic, pathological and clinical concepts in PD. Nat Rev Neurol. 2016;12 (2):65-6. doi: 10.1038/nrneurol.2015.249. PubMed PMID:26782330 .

Kalia, LV, Kalia, SK, Lang, AE. Disease-modifying strategies for Parkinson's disease. Mov Disord. 2015;30 (11):1442-50. doi: 10.1002/mds.26354. PubMed PMID:26208210 .

Kalia, LV, Kalia, SK. α-Synuclein and Lewy pathology in Parkinson's disease. Curr Opin Neurol. 2015;28 (4):375-81. doi: 10.1097/WCO.0000000000000215. PubMed PMID:26110807 .

Kalia, LV, Lang, AE. Parkinson's disease. Lancet. 2015;386 (9996):896-912. doi: 10.1016/S0140-6736(14)61393-3. PubMed PMID:25904081 .

Shah, BB, Chen, R, Zurowski, M, Kalia, LV, Gunraj, C, Lang, AE et al.. Repetitive transcranial magnetic stimulation plus standardized suggestion of benefit for functional movement disorders: an open label case series. Parkinsonism Relat Disord. 2015;21 (4):407-12. doi: 10.1016/j.parkreldis.2015.01.013. PubMed PMID:25737204 .

Kalia, LV, Lang, AE, Hazrati, LN, Fujioka, S, Wszolek, ZK, Dickson, DW et al.. Clinical correlations with Lewy body pathology in LRRK2-related Parkinson disease. JAMA Neurol. 2015;72 (1):100-5. doi: 10.1001/jamaneurol.2014.2704. PubMed PMID:25401511 PubMed Central PMC4399368.

Kalia, LV, Rockman-Greenberg, C, Borys, A, Lang, AE. Tremor in Spinocerebellar Ataxia Type 12. Mov Disord Clin Pract. 2014;1 (1):76-78. doi: 10.1002/mdc3.12015. PubMed PMID:30363887 PubMed Central PMC6183183.

Beilina, A, Rudenko, IN, Kaganovich, A, Civiero, L, Chau, H, Kalia, SK et al.. Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease. Proc Natl Acad Sci U S A. 2014;111 (7):2626-31. doi: 10.1073/pnas.1318306111. PubMed PMID:24510904 PubMed Central PMC3932908.

Dimant, H, Kalia, SK, Kalia, LV, Zhu, LN, Kibuuka, L, Ebrahimi-Fakhari, D et al.. Direct detection of alpha synuclein oligomers in vivo. Acta Neuropathol Commun. 2013;1 :6. doi: 10.1186/2051-5960-1-6. PubMed PMID:24252244 PubMed Central PMC3776213.

Kalia, LV, Lang, AE, Aviv, RI, Masellis, M. Author response. Neurology. 2013;81 (13):1181. . PubMed PMID:24191352 .

AlDakheel, A, Kalia, LV, Lang, AE. Pathogenesis-targeted, disease-modifying therapies in Parkinson disease. Neurotherapeutics. 2014;11 (1):6-23. doi: 10.1007/s13311-013-0218-1. PubMed PMID:24085420 PubMed Central PMC3899477.

Civardi, C, Collini, A, Kalia, LV, Lang, AE, Aviv, RI, Masellis, M et al.. Hemichorea-hemiballism associated with hyperglycemia and a developmental venous anomaly. Neurology. 2013;81 (13):1181. doi: 10.1212/WNL.0b013e3182a7a945. PubMed PMID:24062343 .

Kalia, LV, Kalia, SK, McLean, PJ, Lozano, AM, Lang, AE. α-Synuclein oligomers and clinical implications for Parkinson disease. Ann Neurol. 2013;73 (2):155-69. doi: 10.1002/ana.23746. PubMed PMID:23225525 PubMed Central PMC3608838.

Kalia, LV, Brotchie, JM, Fox, SH. Novel nondopaminergic targets for motor features of Parkinson's disease: review of recent trials. Mov Disord. 2013;28 (2):131-44. doi: 10.1002/mds.25273. PubMed PMID:23225267 .

Kalia, LV, Mozessohn, L, Aviv, RI, da Costa, L, Lang, AE, Shadowitz, S et al.. Hemichorea-hemiballism associated with hyperglycemia and a developmental venous anomaly. Neurology. 2012;78 (11):838-9. doi: 10.1212/WNL.0b013e318249f733. PubMed PMID:22411959 PubMed Central PMC3304947.

Pitcher, GM, Kalia, LV, Ng, D, Goodfellow, NM, Yee, KT, Lambe, EK et al.. Schizophrenia susceptibility pathway neuregulin 1-ErbB4 suppresses Src upregulation of NMDA receptors. Nat Med. 2011;17 (4):470-8. doi: 10.1038/nm.2315. PubMed PMID:21441918 PubMed Central PMC3264662.

Kalia, LV, Kalia, SK, Chau, H, Lozano, AM, Hyman, BT, McLean, PJ et al.. Ubiquitinylation of α-synuclein by carboxyl terminus Hsp70-interacting protein (CHIP) is regulated by Bcl-2-associated athanogene 5 (BAG5). PLoS One. 2011;6 (2):e14695. doi: 10.1371/journal.pone.0014695. PubMed PMID:21358815 PubMed Central PMC3040167.

Kalia, SK, Kalia, LV, McLean, PJ. Molecular chaperones as rational drug targets for Parkinson's disease therapeutics. CNS Neurol Disord Drug Targets. 2010;9 (6):741-53. doi: 10.2174/187152710793237386. PubMed PMID:20942788 PubMed Central PMC3364514.

Kalia, LV, Lee, L, Kalia, SK, Pirouzmand, F, Rapoport, MJ, Aviv, RI et al.. Thoracic myelopathy from coincident fluorosis and epidural lipomatosis. Can J Neurol Sci. 2010;37 (2):276-8. doi: 10.1017/s0317167100010076. PubMed PMID:20437944 .

Ng, D, Pitcher, GM, Szilard, RK, Sertié, A, Kanisek, M, Clapcote, SJ et al.. Neto1 is a novel CUB-domain NMDA receptor-interacting protein required for synaptic plasticity and learning. PLoS Biol. 2009;7 (2):e41. doi: 10.1371/journal.pbio.1000041. PubMed PMID:19243221 PubMed Central PMC2652390.

Kalia, LV, Kalia, SK, Salter, MW. NMDA receptors in clinical neurology: excitatory times ahead. Lancet Neurol. 2008;7 (8):742-55. doi: 10.1016/S1474-4422(08)70165-0. PubMed PMID:18635022 PubMed Central PMC3589564.

Kalia, LV, Pitcher, GM, Pelkey, KA, Salter, MW. PSD-95 is a negative regulator of the tyrosine kinase Src in the NMDA receptor complex. EMBO J. 2006;25 (20):4971-82. doi: 10.1038/sj.emboj.7601342. PubMed PMID:16990796 PubMed Central PMC1618112.

Kalia, LV, O'Connor, PW. Severity of chronic pain and its relationship to quality of life in multiple sclerosis. Mult Scler. 2005;11 (3):322-7. doi: 10.1191/1352458505ms1168oa. PubMed PMID:15957515 .

Kalia, LV, Gingrich, JR, Salter, MW. Src in synaptic transmission and plasticity. Oncogene. 2004;23 (48):8007-16. doi: 10.1038/sj.onc.1208158. PubMed PMID:15489918 .

Salter, MW, Kalia, LV. Src kinases: a hub for NMDA receptor regulation. Nat Rev Neurosci. 2004;5 (4):317-28. doi: 10.1038/nrn1368. PubMed PMID:15034556 .

Kalia, LV, Salter, MW. Interactions between Src family protein tyrosine kinases and PSD-95. Neuropharmacology. 2003;45 (6):720-8. doi: 10.1016/s0028-3908(03)00313-7. PubMed PMID:14529711 .

Fam, SR, Gallagher, CJ, Kalia, LV, Salter, MW. Differential frequency dependence of P2Y1- and P2Y2- mediated Ca 2+ signaling in astrocytes. J Neurosci. 2003;23 (11):4437-44. doi: 10.1523/JNEUROSCI.23-11-04437.2003. PubMed PMID:12805284 PubMed Central PMC6740798.

Kalia, LV. Barriers to women clinician-scientists: a trainee's perspective. Clin Invest Med. 2003;26 (1):15-6. . PubMed PMID:12659464 .

Nong, Y, Huang, YQ, Ju, W, Kalia, LV, Ahmadian, G, Wang, YT et al.. Glycine binding primes NMDA receptor internalization. Nature. 2003;422 (6929):302-7. doi: 10.1038/nature01497. PubMed PMID:12646920 .

Pelkey, KA, Askalan, R, Paul, S, Kalia, LV, Nguyen, TH, Pitcher, GM et al.. Tyrosine phosphatase STEP is a tonic brake on induction of long-term potentiation. Neuron. 2002;34 (1):127-38. doi: 10.1016/s0896-6273(02)00633-5. PubMed PMID:11931747 .

Regan, D, Hajdur, LV, Hong, XH. Two-dimensional aspect ratio discrimination for shape defined by orientation texture. Vision Res. 1996;36 (22):3695-702. doi: 10.1016/0042-6989(96)00083-1. PubMed PMID:8976999 .

Search PubMed

Suneil K. Kalia

Candeias da Silva, C, Fung, WKW, Al-Shorafat, DM, Loh, A, Santyr, B, Kalia, SK et al.. Stimulation-Induced Dyskinesia in STN DBS Patients. Mov Disord Clin Pract. 2025; :. doi: 10.1002/mdc3.70087. PubMed PMID:40249002 .

Tabar, V, Sarva, H, Lozano, AM, Fasano, A, Kalia, SK, Yu, KKH et al.. Phase I trial of hES cell-derived dopaminergic neurons for Parkinson's disease. Nature. 2025; :. doi: 10.1038/s41586-025-08845-y. PubMed PMID:40240592 .

Darmani, G, Ramezanpour, H, Sarica, C, Annirood, R, Grippe, T, Nankoo, JF et al.. Individualized non-invasive deep brain stimulation of the basal ganglia using transcranial ultrasound stimulation. Nat Commun. 2025;16 (1):2693. doi: 10.1038/s41467-025-57883-7. PubMed PMID:40108143 PubMed Central PMC11923056.

Di Luca, DG, Ramirez-Gomez, C, Santyr, B, Fumagalli, M, Germann, J, Kalia, SK et al.. Clinical and Imaging Correlates of Medication Reduction in Globus Pallidus Stimulation for Parkinson's Disease. Mov Disord Clin Pract. 2025; :. doi: 10.1002/mdc3.70042. PubMed PMID:40099474 .

Spencer, KA, Boogers, A, Sumarac, S, Crompton, DBJ, Steiner, LA, Zivkovic, L et al.. Modulating inhibitory synaptic plasticity to restore basal ganglia dynamics in Parkinson's disease. Brain. 2025; :. doi: 10.1093/brain/awaf103. PubMed PMID:40073201 .

Yang, AZ, MacKillop, J, Boutet, A, Fomenko, A, Vetkas, A, Sloan, ME et al.. Deep Brain Stimulation for Substance Use Disorder: Case Report of Fentanyl Use Disorder and Review of the Literature. Can J Neurol Sci. 2025; :1-4. doi: 10.1017/cjn.2025.12. PubMed PMID:39882576 .

Boogers, A, Justich, MB, Montiel, M, Alhashyan, I, Naghdlou, S, Sumarac, S et al.. Reprogramming of updated neurostimulators in chronically implanted patients with Parkinson's disease: A double-blind randomized controlled trial. Brain Stimul. 2025;18 (1):138-140. doi: 10.1016/j.brs.2025.01.006. PubMed PMID:39809410 .

Fomenko, A, Vetkas, A, Davidson, B, Cho, N, Kalia, SK. Stereotactic Frame-Based Targeting of the Posterior Fossa: A Systematic Workflow for the Leksell G Frame. Stereotact Funct Neurosurg. 2025;103 (2):126-131. doi: 10.1159/000543013. PubMed PMID:39675345 .

Fung, WKW, Sumarac, S, Sorrento, G, Santyr, B, Milosevic, L, Lang, AE et al.. Thalamic Local Field Potentials and Closed-Loop Deep Brain Stimulation in Orthostatic Tremor. Mov Disord. 2025;40 (1):141-146. doi: 10.1002/mds.30035. PubMed PMID:39450564 PubMed Central PMC11752987.

Zheng, J, Yebra, M, Schjetnan, AGP, Patel, K, Katz, CN, Kyzar, M et al.. Theta phase precession supports memory formation and retrieval of naturalistic experience in humans. Nat Hum Behav. 2024;8 (12):2423-2436. doi: 10.1038/s41562-024-01983-9. PubMed PMID:39363119 PubMed Central PMC11659172.

Iwasa, SN, Liu, X, Naguib, HE, Kalia, SK, Popovic, MR, Morshead, CM et al.. Electrical Stimulation for Stem Cell-Based Neural Repair: Zapping the Field to Action. eNeuro. 2024;11 (9):. doi: 10.1523/ENEURO.0183-24.2024. PubMed PMID:39256040 PubMed Central PMC11391505.

Sumarac, S, Spencer, KA, Steiner, LA, Fearon, C, Haniff, EA, Kühn, AA et al.. Interrogating basal ganglia circuit function in people with Parkinson's disease and dystonia. Elife. 2024;12 :. doi: 10.7554/eLife.90454. PubMed PMID:39190604 PubMed Central PMC11349293.

Lizarraga, KJ, Gnanamanogaran, B, Al-Ozzi, TM, Cohn, M, Tomlinson, G, Boutet, A et al.. Lateralized Subthalamic Stimulation for Axial Dysfunction in Parkinson's Disease: Exploratory Outcomes and Open-Label Extension. Mov Disord Clin Pract. 2024;11 (11):1421-1426. doi: 10.1002/mdc3.14188. PubMed PMID:39136363 PubMed Central PMC11542286.

Cheyuo, C, Germann, J, Yamamoto, K, Zibly, Z, Krishna, V, Sarica, C et al.. Probabilistic Refinement of Focused Ultrasound Thalamotomy Targeting for Parkinson's Disease Tremor. Mov Disord. 2024;39 (11):2004-2013. doi: 10.1002/mds.29965. PubMed PMID:39120112 .

Steiner, LA, Crompton, D, Sumarac, S, Vetkas, A, Germann, J, Scherer, M et al.. Neural signatures of indirect pathway activity during subthalamic stimulation in Parkinson's disease. Nat Commun. 2024;15 (1):3130. doi: 10.1038/s41467-024-47552-6. PubMed PMID:38605039 PubMed Central PMC11009243.

Leavitt, D, Alanazi, FI, Al-Ozzi, TM, Cohn, M, Hodaie, M, Kalia, SK et al.. Auditory oddball responses in the human subthalamic nucleus and substantia nigra pars reticulata. Neurobiol Dis. 2024;195 :106490. doi: 10.1016/j.nbd.2024.106490. PubMed PMID:38561111 .

Cheyuo, C, Vetkas, A, Sarica, C, Kalia, SK, Hodaie, M, Lozano, AM et al.. Comprehensive characterization of intracranial hemorrhage in deep brain stimulation: a systematic review of literature from 1987 to 2023. J Neurosurg. 2024;141 (2):381-393. doi: 10.3171/2024.1.JNS232385. PubMed PMID:38518284 .

Maheshwari, S, Akram, H, Bulstrode, H, Kalia, SK, Morizane, A, Takahashi, J et al.. Dopaminergic Cell Replacement for Parkinson's Disease: Addressing the Intracranial Delivery Hurdle. J Parkinsons Dis. 2024;14 (3):415-435. doi: 10.3233/JPD-230328. PubMed PMID:38457149 PubMed Central PMC11091588.

Fung, WKW, Justich, MB, Hamani, M, Munhoz, RP, Kalia, SK, Lozano, AM et al.. Remote Deep Brain Stimulation Programming in Canada. Mov Disord Clin Pract. 2024;11 (5):586-589. doi: 10.1002/mdc3.13999. PubMed PMID:38369588 PubMed Central PMC11078478.

Fomenko, A, Fasano, A, Kalia, SK. Another Step Forward for Freezing of Gait in Parkinson's Disease. J Parkinsons Dis. 2024;14 (2):353-355. doi: 10.3233/JPD-230412. PubMed PMID:38251064 PubMed Central PMC10977400.

Tran, S, Heida, TC, Heijs, JJA, Al-Ozzi, T, Sumarac, S, Alanazi, FI et al.. Subthalamic and pallidal neurons are modulated during externally cued movements in Parkinson's disease. Neurobiol Dis. 2024;190 :106384. doi: 10.1016/j.nbd.2023.106384. PubMed PMID:38135193 .

Sarica, C, Conner, CR, Yamamoto, K, Yang, A, Germann, J, Lannon, MM et al.. Trends and disparities in deep brain stimulation utilization in the United States: a Nationwide Inpatient Sample analysis from 1993 to 2017. Lancet Reg Health Am. 2023;26 :100599. doi: 10.1016/j.lana.2023.100599. PubMed PMID:37876670 PubMed Central PMC10593574.

Lannon, M, Duda, T, Mastrolonardo, A, Huang, E, Martyniuk, A, Farrokhyar, F et al.. Economic Evaluations Comparing Deep Brain Stimulation to Best Medical Therapy for Movement Disorders: A Meta-Analysis. Pharmacoeconomics. 2024;42 (1):41-68. doi: 10.1007/s40273-023-01318-y. PubMed PMID:37751075 .

Germann, J, Santyr, B, Boutet, A, Sarica, C, Chow, CT, Elias, GJB et al.. Comparative neural correlates of DBS and MRgFUS lesioning for tremor control in essential tremor. J Neurol Neurosurg Psychiatry. 2024;95 (2):180-183. doi: 10.1136/jnnp-2022-330795. PubMed PMID:37722831 PubMed Central PMC10866130.

Chen, T, Lau, KSK, Hong, SH, Shi, HTH, Iwasa, SN, Chen, JXM et al.. Cryogel-based neurostimulation electrodes to activate endogenous neural precursor cells. Acta Biomater. 2023;171 :392-405. doi: 10.1016/j.actbio.2023.08.056. PubMed PMID:37683963 .

Vetkas, A, Boutet, A, Sarica, C, Germann, J, Gwun, D, Yamamoto, K et al.. Successful magnetic resonance-guided focused ultrasound treatment of tremor in patients with a skull density ratio of 0.4 or less. J Neurosurg. 2024;140 (3):639-647. doi: 10.3171/2023.6.JNS23171. PubMed PMID:37657095 .

Samuel, N, Harmsen, IE, Ding, MYR, Sarica, C, Vetkas, A, Wong, C et al.. Investigation of neurophysiologic and functional connectivity changes following glioma resection using magnetoencephalography. Neurooncol Adv. 2023;5 (1):vdad091. doi: 10.1093/noajnl/vdad091. PubMed PMID:37547265 PubMed Central PMC10403751.

Di Luca, DG, Ramirez-Gomez, C, Germann, J, Santyr, B, Boutet, A, Milosevic, L et al.. Deep Brain Stimulation of the Globus Pallidus Internus and Externus in Multiple System Atrophy. Mov Disord. 2023;38 (11):2121-2125. doi: 10.1002/mds.29573. PubMed PMID:37544011 .

Santyr, B, Loh, A, Vetkas, A, Gwun, D, Fung, WK, Qazi, S et al.. Uncovering neuroanatomical correlates of impaired coordinated movement after pallidal deep brain stimulation. J Neurol Neurosurg Psychiatry. 2024;95 (2):167-170. doi: 10.1136/jnnp-2022-330734. PubMed PMID:37438098 .

Sarica, C, Zemmar, A, Yousefi, O, Yang, AC, Uzuner, A, Sheng, Z et al.. Spinal Cord Stimulation for Parkinson's Disease: A Systematic Review and Meta-Analysis of Pain and Motor Outcomes. Stereotact Funct Neurosurg. 2023;101 (4):244-253. doi: 10.1159/000531089. PubMed PMID:37429256 PubMed Central PMC10614495.

Lang, S, Momi, D, Vetkas, A, Santyr, B, Yang, AZ, Kalia, SK et al.. Computational modeling of whole-brain dynamics: a review of neurosurgical applications. J Neurosurg. 2024;140 (1):218-230. doi: 10.3171/2023.5.JNS23250. PubMed PMID:37382356 .

Basha, D, Kalia, SK, Hodaie, M, Lopez Rios, AL, Lozano, AM, Hutchison, WD et al.. Beta band oscillations in the motor thalamus are modulated by visuomotor coordination in essential tremor patients. Front Hum Neurosci. 2023;17 :1082196. doi: 10.3389/fnhum.2023.1082196. PubMed PMID:37180551 PubMed Central PMC10169705.

Tian, Y, Murphy, MJH, Steiner, LA, Kalia, SK, Hodaie, M, Lozano, AM et al.. Modeling Instantaneous Firing Rate of Deep Brain Stimulation Target Neuronal Ensembles in the Basal Ganglia and Thalamus. Neuromodulation. 2024;27 (3):464-475. doi: 10.1016/j.neurom.2023.03.012. PubMed PMID:37140523 .

Alanazi, FI, Kalia, SK, Hodaie, M, Lopez Rios, AL, Lozano, AM, Milosevic, L et al.. Top-down control of human motor thalamic neuronal activity during the auditory oddball task. NPJ Parkinsons Dis. 2023;9 (1):46. doi: 10.1038/s41531-023-00493-1. PubMed PMID:36973276 PubMed Central PMC10042852.

Balachandar, A, Boutet, A, Vetkas, A, Germann, J, Chan, IYM, Mikulis, D et al.. Reply to: Glioblastoma, IDH-Wildtype, CNS WHO Grade 4, Associated with Deep Brain Stimulation in a Patient with Essential Tremor: Report of a Case with Molecular Characterization and Review of the Literature. Mov Disord Clin Pract. 2023;10 (3):529-530. doi: 10.1002/mdc3.13673. PubMed PMID:36949794 PubMed Central PMC10026296.

Balachandar, A, Boutet, A, Vetkas, A, Germann, J, Chan, IYM, Mikulis, D et al.. The Role of Safe MRI in Diagnosing an Unusual Case of High-Grade Glioma Adjacent to Globus Pallidus Interna DBS Electrode. Mov Disord Clin Pract. 2023;10 (1):138-140. doi: 10.1002/mdc3.13574. PubMed PMID:36704068 PubMed Central PMC9847298.

Vetkas, A, Germann, J, Boutet, A, Samuel, N, Sarica, C, Yamamoto, K et al.. Laser interstitial thermal therapy for the treatment of insular lesions: A systematic review. Front Neurol. 2022;13 :1024075. doi: 10.3389/fneur.2022.1024075. PubMed PMID:36686528 PubMed Central PMC9845884.

Darmani, G, Drummond, NM, Ramezanpour, H, Saha, U, Hoque, T, Udupa, K et al.. Long-Term Recording of Subthalamic Aperiodic Activities and Beta Bursts in Parkinson's Disease. Mov Disord. 2023;38 (2):232-243. doi: 10.1002/mds.29276. PubMed PMID:36424835 .

Cheyuo, C, Germann, J, Yamamoto, K, Vetkas, A, Loh, A, Sarica, C et al.. Connectomic neuromodulation for Alzheimer's disease: A systematic review and meta-analysis of invasive and non-invasive techniques. Transl Psychiatry. 2022;12 (1):490. doi: 10.1038/s41398-022-02246-9. PubMed PMID:36411282 PubMed Central PMC9678946.

O'Halloran, PJ, Henry, J, Amoo, M, Kalyvas, A, Mohan, N, Zadeh, G et al.. LITTing up Gliomas-Is the Future Bright?. World Neurosurg X. 2023;17 :100136. doi: 10.1016/j.wnsx.2022.100136. PubMed PMID:36267388 PubMed Central PMC9576579.

Steiner, LA, Kühn, AA, Geiger, JR, Alle, H, Popovic, MR, Kalia, SK et al.. Persistent synaptic inhibition of the subthalamic nucleus by high frequency stimulation. Brain Stimul. 2022;15 (5):1223-1232. doi: 10.1016/j.brs.2022.08.020. PubMed PMID:36058524 .

Scherer, M, Steiner, LA, Kalia, SK, Hodaie, M, Kühn, AA, Lozano, AM et al.. Single-neuron bursts encode pathological oscillations in subcortical nuclei of patients with Parkinson's disease and essential tremor. Proc Natl Acad Sci U S A. 2022;119 (35):e2205881119. doi: 10.1073/pnas.2205881119. PubMed PMID:36018837 PubMed Central PMC9436336.

Warsi, NM, Yan, H, Wong, SM, Yau, I, Breitbart, S, Go, C et al.. Vagus Nerve Stimulation Modulates Phase-Amplitude Coupling in Thalamic Local Field Potentials. Neuromodulation. 2023;26 (3):601-606. doi: 10.1016/j.neurom.2022.05.001. PubMed PMID:35840521 .

Potel, SR, Marceglia, S, Meoni, S, Kalia, SK, Cury, RG, Moro, E et al.. Advances in DBS Technology and Novel Applications: Focus on Movement Disorders. Curr Neurol Neurosci Rep. 2022;22 (9):577-588. doi: 10.1007/s11910-022-01221-7. PubMed PMID:35838898 .

Loh, A, Boutet, A, Germann, J, Al-Fatly, B, Elias, GJB, Neudorfer, C et al.. A Functional Connectome of Parkinson's Disease Patients Prior to Deep Brain Stimulation: A Tool for Disease-Specific Connectivity Analyses. Front Neurosci. 2022;16 :804125. doi: 10.3389/fnins.2022.804125. PubMed PMID:35812235 PubMed Central PMC9263841.

Loh, A, Elias, GJB, Germann, J, Boutet, A, Gwun, D, Yamamoto, K et al.. Neural Correlates of Optimal Deep Brain Stimulation for Cervical Dystonia. Ann Neurol. 2022;92 (3):418-424. doi: 10.1002/ana.26450. PubMed PMID:35785489 .

Katz, CN, Schjetnan, AGP, Patel, K, Barkley, V, Hoffman, KL, Kalia, SK et al.. A corollary discharge mediates saccade-related inhibition of single units in mnemonic structures of the human brain. Curr Biol. 2022;32 (14):3082-3094.e4. doi: 10.1016/j.cub.2022.06.015. PubMed PMID:35779529 .

Milosevic, L, Sumarac, S, Di Luca, DG, Ramirez-Gomez, C, Hodaie, M, Hutchison, WD et al.. Pallidal neuronal activity in multiple system atrophy type P and Parkinson's disease. Parkinsonism Relat Disord. 2022;101 :15-17. doi: 10.1016/j.parkreldis.2022.06.007. PubMed PMID:35753144 .

Vetkas, A, Germann, J, Elias, G, Loh, A, Boutet, A, Yamamoto, K et al.. Identifying the neural network for neuromodulation in epilepsy through connectomics and graphs. Brain Commun. 2022;4 (3):fcac092. doi: 10.1093/braincomms/fcac092. PubMed PMID:35611305 PubMed Central PMC9123846.

Vetkas, A, Fomenko, A, Germann, J, Sarica, C, Iorio-Morin, C, Samuel, N et al.. Response: Deep brain stimulation targets in epilepsy: Systematic review and meta-analysis of anterior and centromedian thalamic nuclei and hippocampus. Epilepsia. 2022;63 (7):1885-1886. doi: 10.1111/epi.17272. PubMed PMID:35514031 .

Zheng, J, Schjetnan, AGP, Yebra, M, Gomes, BA, Mosher, CP, Kalia, SK et al.. Neurons detect cognitive boundaries to structure episodic memories in humans. Nat Neurosci. 2022;25 (3):358-368. doi: 10.1038/s41593-022-01020-w. PubMed PMID:35260859 PubMed Central PMC8966433.

Lizárraga, KJ, Gnanamanogaran, B, Al-Ozzi, TM, Cohn, M, Tomlinson, G, Boutet, A et al.. Lateralized Subthalamic Stimulation for Axial Dysfunction in Parkinson's Disease: A Randomized Trial. Mov Disord. 2022;37 (5):1079-1087. doi: 10.1002/mds.28953. PubMed PMID:35156734 .

Fasano, A, Gorodetsky, C, Paul, D, Germann, J, Loh, A, Yan, H et al.. Local Field Potential-Based Programming: A Proof-of-Concept Pilot Study. Neuromodulation. 2022;25 (2):271-275. doi: 10.1111/ner.13520. PubMed PMID:35125146 .

Huo, M, Rose, M, van Prooijen, M, Cusimano, MD, Laperriere, N, Heaton, R et al.. Importance of Cobalt-60 Dose Rate and Biologically Effective Dose on Local Control for Intracranial Meningiomas Treated With Stereotactic Radiosurgery. Neurosurgery. 2022;90 (1):140-147. doi: 10.1227/NEU.0000000000001755. PubMed PMID:34982881 .

Vetkas, A, Fomenko, A, Germann, J, Sarica, C, Iorio-Morin, C, Samuel, N et al.. Deep brain stimulation targets in epilepsy: Systematic review and meta-analysis of anterior and centromedian thalamic nuclei and hippocampus. Epilepsia. 2022;63 (3):513-524. doi: 10.1111/epi.17157. PubMed PMID:34981509 .

Samuel, N, Vetkas, A, Pancholi, A, Sarica, C, Loh, A, Germann, J et al.. A Network-Based Approach to Glioma Surgery: Insights from Functional Neurosurgery. Cancers (Basel). 2021;13 (23):. doi: 10.3390/cancers13236127. PubMed PMID:34885236 PubMed Central PMC8656669.

Habets, JGV, Herff, C, Fasano, AA, Beudel, M, Kocabicak, E, Schnitzler, A et al.. Multicenter Validation of Individual Preoperative Motor Outcome Prediction for Deep Brain Stimulation in Parkinson's Disease. Stereotact Funct Neurosurg. 2022;100 (2):121-129. doi: 10.1159/000519960. PubMed PMID:34823246 .

Sasikumar, S, Cohn, M, Harmsen, IE, Loh, A, Cho, SS, Sáenz-Farret, M et al.. Single-Trajectory Multiple-Target Deep Brain Stimulation for Parkinsonian Mobility and Cognition. Mov Disord. 2022;37 (3):635-640. doi: 10.1002/mds.28870. PubMed PMID:34806782 .

Torlakcik, H, Sarica, C, Bayer, P, Yamamoto, K, Iorio-Morin, C, Hodaie, M et al.. Magnetically Guided Catheters, Micro- and Nanorobots for Spinal Cord Stimulation. Front Neurorobot. 2021;15 :749024. doi: 10.3389/fnbot.2021.749024. PubMed PMID:34744678 PubMed Central PMC8565609.

Patel, K, Katz, CN, Kalia, SK, Popovic, MR, Valiante, TA. Volitional control of individual neurons in the human brain. Brain. 2021;144 (12):3651-3663. doi: 10.1093/brain/awab370. PubMed PMID:34623400 PubMed Central PMC8719845.

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Sidiropoulos, C, Hutchison, W, Mestre, T, Moro, E, Prescott, IA, Mizrachi, AV et al.. Bilateral pallidal stimulation for Wilson's disease. Mov Disord. 2013;28 (9):1292-5. doi: 10.1002/mds.25446. PubMed PMID:23554137 .

Matouk, CC, Ellis, MJ, Kalia, SK, Ginsberg, HJ. Skull fracture secondary to application of a Mayfield skull clamp in an adult patient: case report and review of the literature. Clin Neurol Neurosurg. 2012;114 (6):776-8. doi: 10.1016/j.clineuro.2011.12.036. PubMed PMID:22261664 .

Lozano, AM, Kalia, SK. New movement in Parkinson's. Sci Am. 2005;293 (1):68-75. doi: 10.1038/scientificamerican0705-68. PubMed PMID:16008304 .

Kim, RH, Smith, PD, Aleyasin, H, Hayley, S, Mount, MP, Pownall, S et al.. Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress. Proc Natl Acad Sci U S A. 2005;102 (14):5215-20. doi: 10.1073/pnas.0501282102. PubMed PMID:15784737 PubMed Central PMC555037.

Kalia, SK, Lee, S, Smith, PD, Liu, L, Crocker, SJ, Thorarinsdottir, TE et al.. BAG5 inhibits parkin and enhances dopaminergic neuron degeneration. Neuron. 2004;44 (6):931-45. doi: 10.1016/j.neuron.2004.11.026. PubMed PMID:15603737 .

Kalia, SK, Nash, JE, Lozano, AM. To serve and protect? Interventions in the subthalamic nucleus for Parkinson's disease. Commentary on "Ablation of the subthalamic nucleus protects dopaminergic phenotype but not cell survival in a rat model of Parkinson's disease". Exp Neurol. 2004;185 (2):201-3. doi: 10.1016/j.expneurol.2003.10.005. PubMed PMID:14736500 .

Liu, L, Hsu, SS, Kalia, SK, Lozano, AM. Injury and strain-dependent dopaminergic neuronal degeneration in the substantia nigra of mice after axotomy or MPTP. Brain Res. 2003;994 (2):243-52. doi: 10.1016/j.brainres.2003.09.066. PubMed PMID:14642650 .

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